The association of PBX1 polymorphisms with overweight/obesity and metabolic alterations in the Korean population
- Authors
- 반주연; 강순아; 정경희; 김학재; 엄윤경; 김수강; 임성빈; 조봉근; 홍승재; 성연희; 고인송; 정주호
- Issue Date
- Dec-2008
- Publisher
- 한국영양학회
- Keywords
- High-density lipoprotein-cholesterol; overweight/obesity; Pre-B-cell leukemia transcription factor 1 (PBX1); single nucleotide polymorphism (SNP)
- Citation
- Nutrition Research and Practice, v.2, no.4, pp.289 - 294
- Indexed
- KCI
- Journal Title
- Nutrition Research and Practice
- Volume
- 2
- Number
- 4
- Start Page
- 289
- End Page
- 294
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177546
- DOI
- 10.4162/nrp.2008.2.4.289
- ISSN
- 1976-1457
- Abstract
- Pre-B-cell leukemia transcription factor 1 (PBX1), which is located on chromosome 1q23, was recently reported to be associated with type 2
diabetes mellitus. We examined whether single nucleotide polymorphisms (SNPs) of the PBX1 gene are associated with overweight/obesity in a
Korean population. We genotyped 66 SNPs in the PBX1 gene and investigated their association with clinical phenotypes found in 214 overweight/obese
subjects and 160 control subjects using the Affymetrix Targeted Genotyping chip array. Seven SNPs (g.+75186C>T, g.+78350C>A, g.+80646C>T,
g.+138004C>T, g.+185219G>A, g.+191272A>C, and g.+265317T>A) were associated with the risk of obesity in three models (codominant, dominant,
and recessive) (P=0.007-0.05). Haplotype 1 (CAC) and 3 (TAC) of block 3 and haplotype 2 (GGAAT) of block 10 were also strongly associated with the risk of obesity. In the control group, subjects that had homozygote for the major allele for both g.+185219G>A and g.+191272A>C showed lower high density lipoprotein-cholesterol (HDL-C) level compared to those possessing the minor allele, suggesting that the association between the homozygote for the major allele for both g.+185219G>A and g.+191272A>C and HDL-C is attributable to the increased risk of obesity. This study suggests that the PBX1 gene is a possible risk factor in overweight/obese patients.
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