Suppressed production of pro-inflammatory cytokines by LPS-activated macrophages after treatment with Toxoplasma gondii lysate
DC Field | Value | Language |
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dc.contributor.author | Lee, Eun-Jung | - |
dc.contributor.author | Heo, Yoo-Mi | - |
dc.contributor.author | Choi, Jong-Hak | - |
dc.contributor.author | Song, Hyun-Ouk | - |
dc.contributor.author | Ryu, Jae-Sook | - |
dc.contributor.author | Ahn, Myoung-Hee | - |
dc.date.accessioned | 2022-12-21T01:29:29Z | - |
dc.date.available | 2022-12-21T01:29:29Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2008-09 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177972 | - |
dc.description.abstract | During Toxoplasma gondii infection, macrophages, dendritic cells, and neutrophils are important sources of pro-inflammatory cytokines from the host. To counteract the pro-inflammatory activities, T gondii is known to have several mechanisms inducing down-regulation of the host immunity. In the present study, we analyzed the production of pro- and anti-inflammatory cytokines from a human myelomonocytic cell line, THP-1 cells, in response to treatment with T. gondii lysate or lipopolysaccharide (LIPS). Treatment of THP-1 cells with LIPS induced production of IL-12, TNF-alpha, IL-8 and IL-10 Co-treatment of THP-1 cells with T gondii lysate inhibited the LPS-induced IL-12, IL-8 and TNF-alpha expression, but increased the level of IL-10 synergistically. IL-12 and IL-10 production was down-regulated by anti-human toll-like reoeptor (TLR)-2 and TLR4 antibodies. T gondii lysate triggered nuclear factor (NF)-kappa B-dependent IL-8 expression in HEK293 cells transfected with TLR2. It is suggested that immunosuppression induced by T gondii lysate treatment might occur via TLR2-mediated NF-kappa B activation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI | - |
dc.title | Suppressed production of pro-inflammatory cytokines by LPS-activated macrophages after treatment with Toxoplasma gondii lysate | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Jae-Sook | - |
dc.identifier.doi | 10.3347/kjp.2008.46.3.145 | - |
dc.identifier.scopusid | 2-s2.0-56149084596 | - |
dc.identifier.wosid | 000259500600005 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PARASITOLOGY, v.46, no.3, pp.145 - 151 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 145 | - |
dc.citation.endPage | 151 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001277618 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | SUBVERSION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | Toxoplasma gondii | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | toll-like receptor | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.identifier.url | https://www.parasitol.kr/journal/view.php?doi=10.3347/kjp.2008.46.3.145 | - |
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