Correlation of vascular endothelial growth factor-D expression and VEGFR-3-positive vessel density with lymph node metastasis in gastric carcinomaopen access
- Authors
- Choi, Jung-Hye; Oh, Young-Ha; Park, Yong-Wook; Baik, Hong-Kyu; Lee, Young-Yiul; Kim, In-Soon
- Issue Date
- Aug-2008
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- vascular endothelial growth factor D; vascular endothelial growth factor receptor-3; stemach neoplasms
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.23, no.4, pp.592 - 597
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 23
- Number
- 4
- Start Page
- 592
- End Page
- 597
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178062
- DOI
- 10.3346/jkms.2008.23.4.592
- ISSN
- 1011-8934
- Abstract
- Lymph node metastasis is an important prognostic factor in gastric cancer. Vascular endothelial growth factor-D (VEGF-D) is a lymphangiogenic growth factor that activates VEGF receptor (VEGFR)-3, a receptor expressed in the lymphatic endothelium. We investigated the clinical value of VEGF-D expression and VEGFR-3 positive vessel density in gastric carcinoma with regard to lymphangiogenesis. Immunohistochemical staining was used to determine the expression of VEGF-D and VEGFR-3 in specimens from 104 cases of resected gastric cancer. VEGF-D expression was observed in 62.5% of the gastric cancers and in 9.6% of the non-neoplastic gastric tissue. The VEGFR-3-positive vessel density was significantly greater in the VEGF-D positive group than the negative group. VEGF-D expression was significantly associated with lymph node metastasis, increased serum CEA levels, and the non-signet ring cell type. The VEGFR-3-positive vessel density was correlated with tumor size, lymphatic invasion, and lymph node metastasis. The VIEGF-D expression and high VEGFR-3-positive vessel density were significant poor prognostic factors for relapse-tree survival. These results suggest that VEGF-D and VEGFR-3-positive vessel density are potential molecular markers that predict lymphatic involvement in gastric carcinoma.
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