Trichomonas vaginalis-induced neutrophil apoptosis causes anti-inflammatory cytokine production by human monocyte-derived macrophages
- Authors
- Ahn, Myoung Hee; Song, Hyun-Ouk; Ryu, Jae Sook
- Issue Date
- Aug-2008
- Publisher
- WILEY
- Keywords
- anti-inflammatory cytokine; apoptotic neutrophil; macrophage; phagocytosis; Trichomonas vaginalis
- Citation
- PARASITE IMMUNOLOGY, v.30, no.8, pp.410 - 416
- Indexed
- SCIE
SCOPUS
- Journal Title
- PARASITE IMMUNOLOGY
- Volume
- 30
- Number
- 8
- Start Page
- 410
- End Page
- 416
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178071
- DOI
- 10.1111/j.1365-3024.2008.01037.x
- ISSN
- 0141-9838
- Abstract
- Neutrophils are the predominant inflammatory cells found in the vaginal discharge of patients with a Trichomonas vaginalis infection. Neutrophils have a shorter life span than other leucocytes. Our previous study indicated that live T. vaginalis alters Mcl-1 expression and caspase-3 activation, thereby inducing apoptosis of human neutrophils. However, it was previously unknown that the apoptotic neutrophils brought about by T. vaginalis can influence vaginal inflammation. Thus, human monocyte-derived macrophages (HMDM) were incubated with T. vaginalis-induced apoptotic neutrophils. Cytokine production and phagocytosis by HMDM were evaluated by ELISA and myeloperoxidase stain, respectively. HMDM showed increased anti-inflammatory cytokine production (IL-10) and decreased levels of pro-inflammatory cytokines, such as TNF-alpha and IL-6, compared with macrophages alone. Therefore, these results suggest that apoptotic neutrophils caused by T. vaginalis may lead to the resolution of vaginal inflammation by anti-inflammatory cytokine production in the human macrophages.
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