면역억제제로 유발된 범혈구감소증 후 관해에 따른 궤양성 대장염 1예A Case of Ulcerative Colitis with Prolonged Remission Following Azathioprine-Induced Pancytopenia
- Other Titles
- A Case of Ulcerative Colitis with Prolonged Remission Following Azathioprine-Induced Pancytopenia
- Authors
- 이준석; 박영숙; 김남인; 조윤주; 김성환; 이한효; 송문희; 전대원
- Issue Date
- Jun-2008
- Publisher
- 대한장연구학회
- Keywords
- Azathioprine; Pancytopenia; Colitis; Ulcerative
- Citation
- Intestinal research, v.6, no.1, pp.85 - 89
- Indexed
- KCI
OTHER
- Journal Title
- Intestinal research
- Volume
- 6
- Number
- 1
- Start Page
- 85
- End Page
- 89
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178253
- ISSN
- 1598-9100
- Abstract
- Azathioprine (AZA) is widely used for the treatment of inflammatory bowel disease. Bone marrow suppression is a common side effect with AZA treatment. However, data from AZA trials has indicated that a leukocyte count less than 5,000/mm3 was a good predictor of induction and maintenance of remission. Moreover, there is evidence that eradication of sensitized leukocytes by leukapheresis or bone marrow transplantation improves inflammatory bowel disease. We report a case of a patient who had a chronic relapse of ulcerative colitis requiring the frequent use of systemic steroids, but presented prolonged remission following AZA-induced severe pancytopenia. Also colonoscopy showed accelerated healing of diffuse active ulcers following just recovery from pancytopenia.
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