BAF60a interacts with p53 to recruit the SWI/SNF complex
DC Field | Value | Language |
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dc.contributor.author | Oh, Jaehak | - |
dc.contributor.author | Sohn, Dong H. | - |
dc.contributor.author | Ko, Myunggon | - |
dc.contributor.author | Chung, Heekyoung | - |
dc.contributor.author | Jeon, Sung H. | - |
dc.contributor.author | Seong, Rho H. | - |
dc.date.accessioned | 2022-12-21T03:21:28Z | - |
dc.date.available | 2022-12-21T03:21:28Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2008-05 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178685 | - |
dc.description.abstract | To understand the tumor-suppressing mechanism of the SWI/SNF chromatin remodeling complex, we investigated its molecular relationship with p53. Using the pREP4-luc episomal reporter, we first demonstrated that p53 utilizes the chromatin remodeling activity of the SWI/SNF complex to initiate transcription from the chromatin-structured promoter. Among the components of the SWI/SNF complex, we identified BAF60a as a mediator of the interaction with p53 by the yeast two-hybrid assay. p53 directly interacted only with BAF60a, but not with other components of the SWI/SNF complex, such as BRG1, SRG3, SNF5, or BAF57. We found out that multiple residues at the amino acid 108-150 region of BAF60a were involved in the interaction with the tetramerization domain of p53. The N-terminal fragment of BAF60a containing the p53-interacting region as well as small interfering RNA for baf60a inhibited the SWI/SNF complex-mediated transcriptional activity of p53. The uncoupling of p53 with the SWI/SNF complex resulted in the repression of both p53-dependent apoptosis and cell cycle arrest by the regulation of target genes. These results suggest that the SWI/SNF chromatin remodeling complex is involved in the suppression of tumors by the interaction with p53. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | BAF60a interacts with p53 to recruit the SWI/SNF complex | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Heekyoung | - |
dc.identifier.doi | 10.1074/jbc.M705401200 | - |
dc.identifier.scopusid | 2-s2.0-45549083688& | - |
dc.identifier.wosid | 000255340000008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.283, no.18, pp.11924 - 11934 | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 283 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 11924 | - |
dc.citation.endPage | 11934 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | CHROMATIN-REMODELING COMPLEX | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR P53 | - |
dc.subject.keywordPlus | NUCLEAR RECEPTORS | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REPRESSION | - |
dc.subject.keywordPlus | RETINOBLASTOMA PROTEIN | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | SRG3 | - |
dc.subject.keywordPlus | BRG1 | - |
dc.subject.keywordPlus | TRANSACTIVATION | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0021925820492944?via%3Dihub | - |
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