Nanofibrous poly(lactic acid)/hydroxyapatite composite scaffolds for guided tissue regeneration
- Authors
- Jeong, Sung In; Ko, Eun Kyoung; Yum, Jungsuk; Jung, Chul Ho; Lee, Young Moo; Shin, Heungsoo
- Issue Date
- Apr-2008
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Biomimetic; Bone tissue engineering; Electrospinning; Guided tissue regeneration; Hydroxyapatite; Interactions; Osteoblast
- Citation
- MACROMOLECULAR BIOSCIENCE, v.8, no.4, pp.328 - 338
- Indexed
- SCIE
SCOPUS
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 8
- Number
- 4
- Start Page
- 328
- End Page
- 338
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178815
- DOI
- 10.1002/mabi.200700107
- ISSN
- 1616-5187
- Abstract
- The production of nanofibrous PLA/HA composite scaffolds is described. The morphological, mechanical, surface, and thermal properties of the composites were extensively investigated. The results show that the mixture of PLA and HA formed smooth nanofibers without lumps. The incorporation of HA increased the mechanical strength of the nanofibers and changed the morphology, increasing the mean fiber diameter and pore size. Surface and internal properties confirmed that HA was homogeneously distributed inside the nanofibers and oriented towards their surface. The nanofiber composites allowed the adhesion and proliferation of pre-osteoblasts for up to 3 weeks.
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