Stage-specific expression of ankyrin and SOCS box protein-4 (Asb-4) during spermatogenesis
- Authors
- Kim, Soo-Kyoung; Rhim, Si Youn; Lee, Man Ryul; Kim, Jong Soo; Kim, Hyung Jun; Lee, Dong Ryul; Kim, Kye-Seong
- Issue Date
- Apr-2008
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Keywords
- ankyrin-repeat; asb-4; SOCS box; spermatogenesis
- Citation
- MOLECULES AND CELLS, v.25, no.2, pp.317 - 321
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MOLECULES AND CELLS
- Volume
- 25
- Number
- 2
- Start Page
- 317
- End Page
- 321
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178830
- ISSN
- 1016-8478
- Abstract
- Members of the large family of Ash proteins are ubiquitously expressed in mammalian tissues; however, the roles of individual Ash and their function in the developmental testes have not been reported. In this report, we isolated a murine Asb4 from mouse testis. Northern blot analysis revealed that mAsb-4 was expressed only in testes and produced in a stage-specific manner during spermatogenesis. It was expressed in murine testes beginning in the fourth week after birth and extending into adulthood. Pachytene spermatocytes had the highest level of expression. Interestingly, the human homologue of mAsb-4, ASB-4 (hASB-4) was also expressed in human testis. These results suggest that ASB-4 plays pivotal roles in mammalian testis development and spermatogenesis.
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