The BMPs expression and histomorphometric study of β-TCP / rhBMP-2 Grafting on the rabbit cranial bone defects
- Authors
- Lim, Byung-Sup; Jeon, Jae-Yoon; Park, Chang Joo; Im, Jae-Jung; Hwang, Kyung Gyun; Shim, Kwang-Sup
- Issue Date
- Feb-2008
- Publisher
- 대한구강악안면외과학회
- Keywords
- Beta-Tricalcium phosphate; bone graft; Bone Morphogenic Protein; bone substitute; histomorphometry; Immunohistochemistry
- Citation
- 대한구강악안면외과학회지, v.34, no.1, pp.49 - 58
- Indexed
- KCI
- Journal Title
- 대한구강악안면외과학회지
- Volume
- 34
- Number
- 1
- Start Page
- 49
- End Page
- 58
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178967
- ISSN
- 2234-7550
- Abstract
- Objective: The Purpose of the study was to investigate the bone morphogenic protein expression of rhBMP-2(recombinant human bone morphogenic protein-2) as singnaling molecule and β-TCP(Tricalcium phosphate) as a bone substitute and carrier medium of rhBMP-2.
Materials and Methods: 16 rabbits divided into 2 group of each 8 rabbit. Two standardized bone defect, round bilateral defect was made in the cranium of the 8 rabbit of first group, and was grafted with 150~500μm diameter β-TCP 0.25g in one side, which was soaked with rhBMP-2, and autogenous bone was grafted on another side as a positive control. Second group of 8 rabbit, only β-TCP was grafted with same size and same manner. After 2, 4, 8, and 12 weeks, specimen was taken for microscopic immunohiostochemical and histomorphometric analysis.
Result: Grafting β-TCP with rhBMP show the early formation of the bone regenerative factor (BMP-4) and more quantity of new bone formation than only use of β-TCP (8,12 week), even show less new bone formation than autogenous bone.
Conclusion : The experimental study result that β-TCP graft combination with rhBMP-2 as a delivery system is an effective with osteoinductive capacity and biodegradable properties, so that provide clinical availibility of composite use in reconstruction of bony defect.
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