Clinical characteristics and outcome for hepatitis C virus-positive diffuse large B-cell lymphoma
- Authors
- Park, Byeong-Bae; Kim, Jin Seok; Lee, Young-Yuel; Kang, Hye Jin; Ryoo, Baek Yeol; Kang, Jung Hun; Kim, Ho Young; Kim, Bong-Seog; Oh, Sung Yong; Kwon, Hyuk Chan; Won, Jong Ho; Kim, Kihyun; Park, Keunchil; Suh, Cheolwon; Kim, Won Seog
- Issue Date
- Jan-2008
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- hepatitis C virus; diffuse large B-cell lymphoma; clinical outcome
- Citation
- LEUKEMIA & LYMPHOMA, v.49, no.1, pp.88 - 94
- Indexed
- SCIE
SCOPUS
- Journal Title
- LEUKEMIA & LYMPHOMA
- Volume
- 49
- Number
- 1
- Start Page
- 88
- End Page
- 94
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179083
- DOI
- 10.1080/10428190701732861
- ISSN
- 1042-8194
- Abstract
- Several previous studies have addressed the association between hepatitis C virus (HCV) infection and non-Hodgkin lymphoma (NHL), but there are few studies on HCV-related diffuse large B-cell lymphoma (DLBL). We conducted this retrospective study to investigate the distinctive clinical characteristics and outcome for HCV-positive DLBL. We compared the clinical characteristics and outcomes of 32 HCV-positive DLBL cases from nine Korean institutions with those of 371 HCV-negative DLBL cases. A higher percentage of HCV-positive DLBL cases were associated with old age (60) than HCV-negative DLBL cases at diagnosis (59.4% vs. 36.1%, respectively, P=0.009) and HCV-positive cases were less likely than HCV-negative cases to have extranodal involvement (53.1% vs. 71.1%, respectively, P=0.044). The nodal presentation was the only independent factor favorably influencing the event free survival (EFS) in HCV-positive DLBL (HR=0.11, 95% CI; 0.01-0.95, P=0.012). In comparison to patients with HCV-negative DLBL, HCV-positive DLBL patients had a superior complete response rate (P=0.023) and EFS (P=0.02). In Korean patients, HCV-positive DLBL is more common with old age and has less extranodal involvement than does HCV-negative DLBL. The superior survival outcome for HCV-positive DLBL should be verified by further investigation, especially with respect to its correlation with transformed low-grade NHL.
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