Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings
- Authors
- Park, Hee Myung; Kang, Byeong Teck; Lee, Jong Hwan; Jung, Dong In; Park, Chul; Gu, Su Hyun; Jeon, Hyo Won; Jang, Dong Pyo; Lim, Chae Young; Quan, Fu Shi; Kim, Young Bo; Cho, Zang Hee; Woo, Eung Je
- Issue Date
- Dec-2007
- Publisher
- 대한수의학회
- Keywords
- dog; histopathology; ischemic stroke; MCAO; MRI
- Citation
- Journal of Veterinary Science, v.8, no.4, pp.369 - 376
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of Veterinary Science
- Volume
- 8
- Number
- 4
- Start Page
- 369
- End Page
- 376
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179200
- DOI
- 10.4142/jvs.2007.8.4.369
- ISSN
- 1229-845X
- Abstract
- The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery occlusion in four healthy beagle dogs using silicone plugs. They showed neurological signs of forebrain dysfunction such as reduced responsiveness, head turning, circling, postural reaction deficits, perceptual deficits, and hemianopsia. These signs gradually regressed within 4 weeks without therapy. On magnetic resonance imaging, T2 hyperintensity and T1 hypointensity were found in the cerebral cortex and basal ganglia. These lesions were well-defined and sharply demarcated from adjacent brain parenchyma with a homogenous appearance.
No abnormalities of the cerebrospinal fluid were observed. At necropsy, atrophic and necrotic lesions were observed in the cerebral cortex. The cerebral cortex, basal ganglia, and thalamus were partially unstained with triphenyl- tetrazolium chloride. Histopathologically, typical features of infarction were identified in cortical and thalamic lesions. This study demonstrates that our canine model resembles the conditions of real stroke patients.
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