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Isolation of CD24(high) and CD24(low/-) cells from MCF-7: CD24 expression is positively related with proliferation, adhesion and invasion in MCF-7
- Authors
- Kim, Hee Joung; Kim, Jong Bin; Lee, Kyung-Min; Shin, Incheol; Han, Wonshik; Ko, Eunyoung; Bae, Ji-Yeon; Noh, Dong-Young
- Issue Date
- Dec-2007
- Publisher
- Elsevier BV
- Keywords
- CD24; MCF-7; proliferation; adhesion; invasion
- Citation
- Cancer Letters, v.258, no.1, pp 98 - 108
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- Cancer Letters
- Volume
- 258
- Number
- 1
- Start Page
- 98
- End Page
- 108
- ISSN
- 0304-3835
1872-7980
- Abstract
- CD24 has been reported to have a role in metastasis of several malignancies including breast cancer. We investigated the effect of CD24 expression on biologic features in human breast cancer cells, and found that CD24 expression is associated with more rapid growth and enhanced ability of adhesion and invasion in MCF-7. The proportion of cells was higher in synthetic phase and lower in arrestic phase for CD24(high) than for CD24(low/-) cells. Cyclin D1 and p27 had stronger expressions in CD24(low/-) cells than CD24(high) cells. These suggested one possible pathway for CD24 effect on proliferation.
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Related Researcher
- Shin, In cheol
- COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF LIFE SCIENCE)