PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C-elegans
DC Field | Value | Language |
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dc.contributor.author | Ko, Kyung Min | - |
dc.contributor.author | Lee, Wonhae | - |
dc.contributor.author | Yu, Jae-Ran | - |
dc.contributor.author | Ahnn, Joohong | - |
dc.date.accessioned | 2022-12-21T05:37:11Z | - |
dc.date.available | 2022-12-21T05:37:11Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2007-11 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179417 | - |
dc.description.abstract | Inorganic pyrophosphatase ( PPase) catalyzes the hydrolysis of inorganic pyrophosphate (PPi) into phosphate ( Pi), which provides a thermodynamic driving force for important biosynthetic reactions. The nematode Caenorhabditis elegans gene C47E12.4 encodes a PPase (PYP-1) which shows 54% amino acid identity with human PPase. PYP-1 exhibits specific enzyme activity and is mainly expressed in the intestinal and nervous system. A null mutant of pyp-1 reveals a developmental arrest at early larval stages and exhibits gross defects in intestinal morphology and function. The larval arrest phenotype was successfully rescued by reintroduction of the pyp-1 gene, suggesting that PYP-1 is required for larval development and intestinal function in C. elegans. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C-elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahnn, Joohong | - |
dc.identifier.doi | 10.1016/j.febslet.2007.10.047 | - |
dc.identifier.scopusid | 2-s2.0-36048956445 | - |
dc.identifier.wosid | 000253487900019 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.581, no.28, pp.5445 - 5453 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 581 | - |
dc.citation.number | 28 | - |
dc.citation.startPage | 5445 | - |
dc.citation.endPage | 5453 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | PROTEIN EXPRESSION | - |
dc.subject.keywordPlus | PROTEOMIC ANALYSIS | - |
dc.subject.keywordPlus | ROUNDWORM ASCARIS | - |
dc.subject.keywordPlus | MOLECULAR-CLONING | - |
dc.subject.keywordPlus | CONSERVATION | - |
dc.subject.keywordPlus | GENETICS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | FERTILITY | - |
dc.subject.keywordAuthor | inorganic pyrophosphatase | - |
dc.subject.keywordAuthor | PYP-1 | - |
dc.subject.keywordAuthor | deletion mutant | - |
dc.subject.keywordAuthor | larval arrest | - |
dc.subject.keywordAuthor | C. elegans | - |
dc.identifier.url | https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2007.10.047 | - |
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