PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C-elegansopen access
- Authors
- Ko, Kyung Min; Lee, Wonhae; Yu, Jae-Ran; Ahnn, Joohong
- Issue Date
- Nov-2007
- Publisher
- WILEY
- Keywords
- inorganic pyrophosphatase; PYP-1; deletion mutant; larval arrest; C. elegans
- Citation
- FEBS LETTERS, v.581, no.28, pp.5445 - 5453
- Indexed
- SCIE
SCOPUS
- Journal Title
- FEBS LETTERS
- Volume
- 581
- Number
- 28
- Start Page
- 5445
- End Page
- 5453
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179417
- DOI
- 10.1016/j.febslet.2007.10.047
- ISSN
- 0014-5793
- Abstract
- Inorganic pyrophosphatase ( PPase) catalyzes the hydrolysis of inorganic pyrophosphate (PPi) into phosphate ( Pi), which provides a thermodynamic driving force for important biosynthetic reactions. The nematode Caenorhabditis elegans gene C47E12.4 encodes a PPase (PYP-1) which shows 54% amino acid identity with human PPase. PYP-1 exhibits specific enzyme activity and is mainly expressed in the intestinal and nervous system. A null mutant of pyp-1 reveals a developmental arrest at early larval stages and exhibits gross defects in intestinal morphology and function. The larval arrest phenotype was successfully rescued by reintroduction of the pyp-1 gene, suggesting that PYP-1 is required for larval development and intestinal function in C. elegans.
- Files in This Item
-
- Appears in
Collections - 서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.