장기적인 간헐적 산소 투여가 흰 쥐의 인지기능에 미치는 영향Effects of Long-Term Intermittent Oxygen Administration on the Cognitive Function in Rats
- Other Titles
- Effects of Long-Term Intermittent Oxygen Administration on the Cognitive Function in Rats
- Authors
- 김찬; 구승룡; 김철현; 김경헌; 김동원; 안해철
- Issue Date
- Jun-2007
- Publisher
- 대한마취통증의학회
- Keywords
- cognitive function; long-term oxygen administration; water maze.; cognitive function; long-term oxygen administration; water maze.
- Citation
- Korean Journal of Anesthesiology, v.52, no.6, pp.687 - 693
- Indexed
- KCI
- Journal Title
- Korean Journal of Anesthesiology
- Volume
- 52
- Number
- 6
- Start Page
- 687
- End Page
- 693
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179932
- DOI
- 10.4097/kjae.2007.52.6.687
- ISSN
- 2005-6419
- Abstract
- Background: Several studies have demonstrated that the transient administration of oxygen improves cognitive performance. However, the effect of long-term oxygen administration remains unknown. This study investigated the impact of long-term oxygen administration on cognitive enhancement.
Methods: Six week old Sprague-Dawley rats (n = 46) were randomly allocated to one of three groups: the control (Control; n = 15), 30 min/day oxygen administration (Oxy30min; n = 16) and 60 min/day oxygen administration groups (Oxy60min; n = 15). The rats in all three groups were administered air or oxygen for 10 weeks. The Morris water maze test was employed to assess the latency (L & Lt), dwelling time (DT) and the total fraction above the mean dwelling time (FmDT) for cognitive performance.
Results: Compared to the control group, the Oxy30min and Oxy60min groups showed no differences in their L and Lt. There was a dose-response trend due to oxygen administration. Compared to the control group, the Oxy60min group had a significantly improved DT (P < 0.05). The FmDT also significantly increased in both of the oxygen administration groups, which also showed a dose-response trend (P < 0.05).
Conclusions: The present results suggest that long-term (10 weeks) oxygen administration can dose-dependently enhance cognitive performance.
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