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Water intoxication following low-dose intravenous cyclophosphamideopen access
- Authors
- Tai, Yeon Ko; Bae, Sang-Cheol; Park, Joon Sung; Chang, Hwa Lee; Moon, Hyang Park; Chong, Myung Kang; Kim, Gheun Ho
- Issue Date
- Jun-2007
- Publisher
- Korean Society of Electrolyte and Blood Pressure Research
- Keywords
- Cyclophosphamide; Hyponatremia; Lupus nephritis; Water intoxication
- Citation
- Electrolyte and Blood Pressure, v.5, no.1, pp.50 - 54
- Indexed
- SCOPUS
KCI
OTHER
- Journal Title
- Electrolyte and Blood Pressure
- Volume
- 5
- Number
- 1
- Start Page
- 50
- End Page
- 54
- ISSN
- 1738-5997
- Abstract
- Cyclophosphamide is frequently used for the treatment of severe lupus nephritis, but is very rarely associated with dilutional hyponatremia. Recently we experienced a case of water intoxication following low-dose intravenous cyclophosphamide. Five hours after one dose of intravenous pulse cyclophosphamide 750 mg, the patient developed nausea, vomiting, and general weakness. Serum sodium concentration revealed 114 mEq/L and her hyponatremia was initially treated with hypertonic saline infusion. Then her serum sodium concentration rapidly recovered to normal with water restriction alone. During the course of intravenous pulse cyclophosphamide therapy, one must be aware of the possibility of significant water retention.
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Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
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Related Researcher
- Kim, Gheun-Ho
- COLLEGE OF MEDICINE (DEPARTMENT OF INTERNAL MEDICINE)