대장 선종의 위험 인자로 복부 비만 및 인슐린 저항성에 대한 연구Abdominal obesity, insulin resistance, and the risk of colonic adenoma.
- Other Titles
- Abdominal obesity, insulin resistance, and the risk of colonic adenoma.
- Authors
- 이항락; 손병관; 이오영; 전용철; 한동수; 손주현; 윤병철; 최호순; 함준수; 이민호; 이동후; 기춘석
- Issue Date
- Mar-2007
- Publisher
- 대한소화기학회
- Keywords
- Colonic adenoma; Obesity; Insulin resistance; Colonic adenoma; Obesity; Insulin resistance
- Citation
- The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, v.49, no.3, pp.147 - 151
- Indexed
- SCOPUS
KCI
- Journal Title
- The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
- Volume
- 49
- Number
- 3
- Start Page
- 147
- End Page
- 151
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/180359
- ISSN
- 1598-9992
- Abstract
- BACKGROUND/AIMS: Abdominal obesity and hyperinsulinemia or insulin resistance are of interest in connection with colon carcinogenesis. We conducted a prospective case controlled study for the evaluation of relationship between abdominal obesity, insulin resistance, and colorectal adenoma. METHODS: Fifty patients with colorectal adenoma and fifty healthy subjects were included in this study. Total colonoscopic examinations were performed in all the subjects. Fasting blood sugar (FBS), insulin, homeostasis model assessment (HOMA-IR), triglyceride (TG), cholesterol (CROL), BMI (body mass index), WHR (waist hip ratio), percent body fat (PBF) and obesity degree (OD) were measured. HOMA-IR was considered to represent insulin resistance. Diabetic patients were excluded from this study. RESULTS: There were no differences in sex, serum insulin, FBS, HOMA-IR, TG, CROL between adenoma and control group. Subjects with high BMI, WHR, percent body fat, and obesity were more likely to have colonic adenoma. Multiple logistic regression analysis after adjusting confounding factors, had revealed that WHR was the most important independent risk factor for colon adenoma. CONCLUSIONS: Abdominal obesity was most closely related to colonic adenoma. However, insulin resistance was not related to colonic adenoma. A larger case controlled study is needed.
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