Midazolam이 가토의 대뇌동맥 평활근세포의 외향성 K+ 전류에 미치는 영향The Effect of Midazolam on Outward K+ Channel Currents in Rabbit Cerebral Arterial Smooth Muscle Cells
- Other Titles
- The Effect of Midazolam on Outward K+ Channel Currents in Rabbit Cerebral Arterial Smooth Muscle Cells
- Authors
- 신영철; 심재항; 전우재; 조상윤; 신우종; 김경헌; 염종훈
- Issue Date
- Jan-2007
- Publisher
- 대한마취통증의학회
- Keywords
- midazolam; outward K currents; rabbit cerebral arterial smooth muscle cell.; midazolam; outward K currents; rabbit cerebral arterial smooth muscle cell.
- Citation
- Korean Journal of Anesthesiology, v.52, no.1, pp.67 - 71
- Indexed
- KCI
- Journal Title
- Korean Journal of Anesthesiology
- Volume
- 52
- Number
- 1
- Start Page
- 67
- End Page
- 71
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/180532
- DOI
- 10.4097/kjae.2007.52.1.67
- ISSN
- 2005-6419
- Abstract
- Background: Midazolam has a direct relaxing effect on vascular smooth muscle, but the mechanisms that this agent produces muscle relaxation are not fully understood. The current study was performed to identify the effects of the midazolam on K+ channels current in rabbit cerebral arterial smooth muscle cells.
Methods: Whole cell patch-clamp recording technique was used to evaluate the effects of midazolam (0.1 to 100μM) on outward K+ channel currents in dispersed rabbit cerebral arterial smooth muscle cells.
Results: Outward K+ currents of rabbit cerebral artery smooth muscle cells were voltage-dependent. Midazolam (10, 100μM) tested significantly inhibited outward K+ currents in a dose-dependent manner and half-blocking concentration (IC50) was 15.94μM at 60 mV.
Conclusions: Midazolam inhibit outward K+ currents of rabbit cerebral arterial smooth muscle cells. Further study will be needed to determine the effect of midazolam on calcium channel current because it is unclear if the inhibitory effect of midazolam on outward K+current induces vasoconstriction. (Korean J Anesthesiol 2007; 52: 67~71)
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