만성골수성백혈병의 임프아세포위기에서 발생한 종양용해증후군Tumor Lysis Syndrome in Lymphoblastic Crisis of CML
- Other Titles
- Tumor Lysis Syndrome in Lymphoblastic Crisis of CML
- Authors
- 이덕주; 최치언; 이충식; 이학현; 박진규; 최정혜; 이영열; 김인순
- Issue Date
- Jun-2006
- Publisher
- 대한혈액학회
- Keywords
- Tumor lysis syndrome; Chronic myelogeous leukemia; Blast crisis
- Citation
- Blood Research, v.41, no.2, pp.8 - 8
- Indexed
- KCI
- Journal Title
- Blood Research
- Volume
- 41
- Number
- 2
- Start Page
- 8
- End Page
- 8
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181316
- ISSN
- 2287-979X
- Abstract
- Tumor lysis syndrome (TLS) defines the metabolic derangements that occur with tumor breakdown following the initiation of cytotoxic therapy. TLS results from the rapid destruction of malignant cells and the abrupt release of intracellular materials and their metabolites into the extracellular space. The syndrome causes hyperuricemia, hyperkalemia, hyperphosphatemia, secondary hypocalcemia and uremia. It can result in acute renal failure and be fatal. Early recognition of patient at risk and preventive measures are important. There is a high incidence of TLS in tumors with high proliferative rates and large burden such as acute lymphoblastic leukemia and Burkitt's lymphoma. It less commonly occurs in solid tumors such as testicular cancer, breast cancer and small cell lung cancer. There are only complicated in CML in blast crisis. So we report a 45-yr-old woman presenting with TLS associated with CML in lymphoblastic crisis after the initiation of cytotoxic chemotherapy.
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