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폐경기모델 백서 해마에서 식물성 에스트로젠에 의한 뇌-혈액장벽 유전자 occludin 발현의 변화Change in the Expression of Occludin, a Gene for Blood-Brain Barrier by Phytoestrogens in Hippocampus of Rat Model for Menopause
- Other Titles
- Change in the Expression of Occludin, a Gene for Blood-Brain Barrier by Phytoestrogens in Hippocampus of Rat Model for Menopause
- Issue Date
- Apr-2006
- Publisher
- 한국환경생물학회
- Keywords
- occludin; brain; isoflavone; ovariectomy; rat의 노인성 치매의 위험을 유의하게 낮추며; 정상적 인지기능이 에스트로젠 감소에 의해 손상될 수 있으며; 난소절제에 따른 인지기능 저하가 호르몬 대체요법에 의해예방된다고 보고되어 갱년기 호르몬 대체요법의 주 적응증의 하나로 폐경 여성의 퇴행적 뇌질환의 예방과 개선이 부상되었다(Kim et al. 2000). 그러나 에스트로젠 요법은 자궁암이나 유방암 발생 등의 부작
- Citation
- 환경생물, v.24, no.2, pp 166 - 171
- Pages
- 6
- Indexed
- KCICANDI
- Journal Title
- 환경생물
- Volume
- 24
- Number
- 2
- Start Page
- 166
- End Page
- 171
- ISSN
- 1226-9999
2287-7851
- Abstract
- - To elucidate the effect of phytoestrogens on the prevention of neurodegenerativedisease in postmenopausal women, the expression of occludin which build up the blood-brainbarrier was examined in hippocampus following oral administration of estrogen (E2), genistein,diadzein or combination of genistein and diadzein in ovariectomized (OVX) female rats. E2significantly increased occludin mRNA level in OVX rat hippocampus, suggesting that estrogen isa physiological regulator for structural integrity of the blood-brain barrier in hippocampus.hippocampus, suggesting that isoflavone diet may be effective for protection of structuralintegrity of blood-brain barrier in hippocampus from degenerative changes in estrogendeficiency.
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