Heparin-binding epidermal growth factor (HB-EGF) may improve embryonic development and implantation by increasing vitronectin receptor (integrin alpha nu beta 3) expression in peri-implantation mouse embryos
DC Field | Value | Language |
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dc.contributor.author | Lim, Jung An | - |
dc.contributor.author | Lee, Dong Ryul | - |
dc.contributor.author | Song, Haeng-Seok | - |
dc.contributor.author | Kim, Kye-Seong | - |
dc.contributor.author | Yoon, Tae Ki | - |
dc.contributor.author | Gye, Myung Chan | - |
dc.contributor.author | Kim, Moon Kyoo | - |
dc.date.accessioned | 2022-12-21T11:51:21Z | - |
dc.date.available | 2022-12-21T11:51:21Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2006-03 | - |
dc.identifier.issn | 1058-0468 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181687 | - |
dc.description.abstract | Purpose: This study investigated the effects of HB-EGF on expression of integrin alpha nu beta 3 and implantation of embryos. Methods: Two-cell embryos were recovered and cultured with or without 10 ng/mL HB-EGF for 96h. Expression of integrin alpha nu beta 3 in cultured embryos was examined by real time-RT-PCR and immunofluorescence analysis; embryos were cultured with or without HB-EGF, then transferred into the uteri of pseudo-pregnant female mice in order to analyze their implantation rate. Results: HB-EGF improved embryonic hatching and outgrowth during extended culture, and up-regulated expression of integrin alpha nu beta 3 in both the preimplantation embryo and outgrowing blastocyst. Also, integrin alpha nu beta 3 subunits were localized at the pericellular borders and cell-cell contact areas. The number of successful implantation sites of transferred HB-EGF-treated embryos in the uterus was increased when compared to number of implantation sites with non-treated controls. Conclusions: HB-EGF may improve implantation by accelerating expression of integrin alpha nu beta 3 in peri-implantation mouse embryos. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.title | Heparin-binding epidermal growth factor (HB-EGF) may improve embryonic development and implantation by increasing vitronectin receptor (integrin alpha nu beta 3) expression in peri-implantation mouse embryos | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kye-Seong | - |
dc.contributor.affiliatedAuthor | Gye, Myung Chan | - |
dc.identifier.doi | 10.1007/s10815-006-9021-9 | - |
dc.identifier.scopusid | 2-s2.0-33745022334 | - |
dc.identifier.wosid | 000238426100002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, v.23, no.3, pp.111 - 119 | - |
dc.relation.isPartOf | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | - |
dc.citation.title | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | - |
dc.citation.volume | 23 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 119 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalResearchArea | Reproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Reproductive Biology | - |
dc.subject.keywordPlus | HUMAN ENDOMETRIUM | - |
dc.subject.keywordPlus | MENSTRUAL-CYCLE | - |
dc.subject.keywordPlus | UTERUS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | TIME | - |
dc.subject.keywordAuthor | embryonic development | - |
dc.subject.keywordAuthor | HB-EGF | - |
dc.subject.keywordAuthor | integrin alpha nu beta 3 | - |
dc.subject.keywordAuthor | implantation | - |
dc.subject.keywordAuthor | mouse | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10815-006-9021-9 | - |
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