Expression of four growth factors in recessed extraocular muscles of rabbits
- Authors
- Shin, Sun Young; Paik, Doo Jin
- Issue Date
- Mar-2006
- Publisher
- SLACK INC
- Citation
- OPHTHALMIC SURGERY LASERS & IMAGING, v.37, no.2, pp.129 - 137
- Indexed
- SCIE
SCOPUS
- Journal Title
- OPHTHALMIC SURGERY LASERS & IMAGING
- Volume
- 37
- Number
- 2
- Start Page
- 129
- End Page
- 137
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181714
- DOI
- 10.3928/1542-8877-20060301-08
- ISSN
- 1542-8877
- Abstract
- BACKGROUND AND OBJECTIVE: The study was designed to determine the temporal expression of insulin-like growth factor (IGF)-I, IGF-II, basic fibroblast factor 2 (bFGF-2), and transforming growth factor beta 1 (TGF-beta 1) in recessed extraocular muscles. MATERIALS AND METHODS: Sixteen eyes of eight rabbits were subjected to conventional 4 mm recession of superior rectus muscles. Two rabbits were untreated as control. The rabbits were killed and their eyes were enucleated at 3 (group 3), 6 (group 6), 24 (group 24), and 72 (group 72) hours after the operation (two rabbits per group), and the expression of IGF-I, IGF-II, bFGF-2, and TGF-beta 1 was immunohistochemically examined. RESULTS: The peak levels of IGF-I, IGF-II, and TGF-beta 1 expression were observed in groups 24, 6, and 3, respectively. However, bFGF-2 was less expressed than the other growth factors in all groups. CONCLUSIONS: IGF-I, IGF-II, bFGF-2, and TGF-beta 1 in regenerating muscle cells were expressed by different kinetics, suggesting a distinct role of each growth factor during wound healing after recession of extraocular muscles.
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