신경전달물질 방출 저해제 S8877이 신경세포와 PC12 세포의 돌기신장에 미치는 영향Effect of S9940, an Inhibitor of Exocytosis on Neurite Extension in Rat Hippocampal Neurons and PC12 Cells
- Other Titles
- Effect of S9940, an Inhibitor of Exocytosis on Neurite Extension in Rat Hippocampal Neurons and PC12 Cells
- Authors
- 강주섭; 김종욱; 지옥화; 엄애선; 이윤식
- Issue Date
- Feb-2006
- Publisher
- 대한암예방학회
- Keywords
- Neuron; Exocytosis; Inhibitor; Neurophil; β-glucuronidas
- Citation
- 대한암예방학회지, v.11, no.1, pp.30 - 38
- Indexed
- KCI
OTHER
- Journal Title
- 대한암예방학회지
- Volume
- 11
- Number
- 1
- Start Page
- 30
- End Page
- 38
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181741
- ISSN
- 2288-3649
- Abstract
- We identified S8877, a novel microbial metabolite from Streptomyces spp., to inhibit the release of neurotransmitter form rat hippocampal neuron and PC12 cells. S8877 is an inhibitor of trifiated norepinephrine ([3H]-NE) release in high K+ buffer solution containing ionomycin, indicating that S8877 inhibits neurotransmitter release after the influx of Ca2+ ions. We also examined the effect of S8877 on β-glucuronidase release from guinea pig neurophils and on the neurite extension of rat hippocampal neurons and PC12 cells. As a result, S8877 increased β-glucruonidas release: when treated with 5μg/ml of S8877, which prevented [3H]-NE release, and the inhibition of neurite extension for both rat hippocampal neurons and PC12 cells was observed.
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Collections - 서울 생활과학대학 > 서울 식품영양학과 > 1. Journal Articles
- 서울 의과대학 > 서울 약리학교실 > 1. Journal Articles
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