Prognostic implication of telomerase activity in patients with brain tumorsopen access
- Authors
- Kim, Choong Hyun; Cheong, Jin Hwan; Bak, Koang Hum; Kim, Jae Min; Oh, Suck Jun
- Issue Date
- Feb-2006
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- brain neoplasms; glioma; survival; telomerase
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.21, no.1, pp.126 - 130
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 21
- Number
- 1
- Start Page
- 126
- End Page
- 130
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181767
- DOI
- 10.3346/jkms.2006.21.1.126
- ISSN
- 1011-8934
- Abstract
- Telomerase adds telomeric repeats to the ends of telomeres to compensate for their progressive loss. A favorable prognosis is associated with low or no telomerase in some tumors. The authors investigated whether telomerase activity is associated with survival of patients with brain tumors. Sixty-two consecutive patients with brain tumors underwent surgery, and their surgical specimens were investigated. The patients were pathologically categorized as group I (aggressive group) and group 11 (non-aggressive group). Telomerase activity was examined by the telomeric repeat amplification protocol (TRAP) assay. The median time was calculated in association with overall survival and progression-free survival in each group. The significant difference was noted in telomerase activity between high-grade gliomas and low-grade gliomas (p = 0.022). Telomerase activity was significantly associated with the median overall survival and progression-free survival in all tumors of the aggressive group. On the other hand, the median overall survival in the non-aggressive group was not dependent on telomerase activity, while the median progression-free survival was. Our data suggests that telomerase is an important prognostic indicator of survival in patients with brain tumors.
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