Prolonged Use of Carnitine-Orotate Complex (Godex®) Is Associated with Improved Mortality: A Nationwide Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Park, Kye-Yeung | - |
dc.contributor.author | Hong, Sangmo | - |
dc.contributor.author | Kim, Kyung-Soo | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Park, Cheol-Young | - |
dc.date.accessioned | 2023-01-25T09:18:24Z | - |
dc.date.available | 2023-01-25T09:18:24Z | - |
dc.date.created | 2023-01-05 | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 2075-4426 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/182178 | - |
dc.description.abstract | Despite its hepatoprotective effects and favorable metabolic effects, the association between carnitine-orotate complex (Godex®) intake and mortality has never been investigated. We enrolled 13,413 adults who underwent national health examination and were prescribed the carnitine-orotate complex. Subjects were classified into three groups based on duration of using carnitine-orotate complex: <30, 30–180, and ≥180 days and were followed-up until 2019. Hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality were estimated using Cox proportional hazards regression. During the follow-up period, 708 deaths were documented. Adjusted HR of mortality was 0.69 (95% CI 0.51–0.92) in those who used carnitine-orotate complex for ≥180 days compared to those who used it for <30 days. Use of carnitine-orotate complex for ≥180 days was associated with significantly reduced mortality in individuals with metabolic risk factors such as obesity, metabolic syndrome, dyslipidemia, and fatty liver than the shorter period of use. A significant interaction was observed in individuals with type 2 diabetes (HR 0.43, 95% CI 0.29–0.63, p-value 0.001). In this nationwide study, longer use of carnitine-orotate complex was associated with improved mortality compared to a shorter period of use, and the risk reductions were prominent in individuals with metabolic risk factors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Prolonged Use of Carnitine-Orotate Complex (Godex®) Is Associated with Improved Mortality: A Nationwide Cohort Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Sangmo | - |
dc.identifier.doi | 10.3390/jpm12121970 | - |
dc.identifier.scopusid | 2-s2.0-85144673922 | - |
dc.identifier.wosid | 000900966100001 | - |
dc.identifier.bibliographicCitation | Journal of Personalized Medicine, v.12, no.12, pp.1 - 12 | - |
dc.relation.isPartOf | Journal of Personalized Medicine | - |
dc.citation.title | Journal of Personalized Medicine | - |
dc.citation.volume | 12 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Health Care Sciences & ServicesGeneral & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Health Care Sciences & ServicesMedicine, General & Internal | - |
dc.subject.keywordPlus | FATTY LIVER-DISEASE | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | TYPE-2 | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | SUPPLEMENTATION | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | FRUCTOSE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | BODY | - |
dc.subject.keywordAuthor | cardiometabolic risk factors | - |
dc.subject.keywordAuthor | carnitine | - |
dc.subject.keywordAuthor | epidemiologic study | - |
dc.subject.keywordAuthor | metabolic diseases | - |
dc.subject.keywordAuthor | mortality | - |
dc.identifier.url | https://www.mdpi.com/2075-4426/12/12/1970 | - |
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