Prolonged Use of Carnitine-Orotate Complex (Godex®) Is Associated with Improved Mortality: A Nationwide Cohort Studyopen access
- Authors
- Park, Kye-Yeung; Hong, Sangmo; Kim, Kyung-Soo; Han, Kyungdo; Park, Cheol-Young
- Issue Date
- Dec-2022
- Publisher
- MDPI
- Keywords
- cardiometabolic risk factors; carnitine; epidemiologic study; metabolic diseases; mortality
- Citation
- Journal of Personalized Medicine, v.12, no.12, pp.1 - 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Personalized Medicine
- Volume
- 12
- Number
- 12
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/182178
- DOI
- 10.3390/jpm12121970
- ISSN
- 2075-4426
- Abstract
- Despite its hepatoprotective effects and favorable metabolic effects, the association between carnitine-orotate complex (Godex®) intake and mortality has never been investigated. We enrolled 13,413 adults who underwent national health examination and were prescribed the carnitine-orotate complex. Subjects were classified into three groups based on duration of using carnitine-orotate complex: <30, 30–180, and ≥180 days and were followed-up until 2019. Hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality were estimated using Cox proportional hazards regression. During the follow-up period, 708 deaths were documented. Adjusted HR of mortality was 0.69 (95% CI 0.51–0.92) in those who used carnitine-orotate complex for ≥180 days compared to those who used it for <30 days. Use of carnitine-orotate complex for ≥180 days was associated with significantly reduced mortality in individuals with metabolic risk factors such as obesity, metabolic syndrome, dyslipidemia, and fatty liver than the shorter period of use. A significant interaction was observed in individuals with type 2 diabetes (HR 0.43, 95% CI 0.29–0.63, p-value 0.001). In this nationwide study, longer use of carnitine-orotate complex was associated with improved mortality compared to a shorter period of use, and the risk reductions were prominent in individuals with metabolic risk factors.
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