Regional lymph node recurrence after stereotactic body radiation therapy for lung cancer: Patterns of recurrence, treatment approaches, and clinical outcomes (KROG 21-09)
DC Field | Value | Language |
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dc.contributor.author | Lee, Tae Hoon | - |
dc.contributor.author | Shin, Hyunju | - |
dc.contributor.author | Ahn, Yong Chan | - |
dc.contributor.author | Kang, Min Kyu | - |
dc.contributor.author | Song, Changhoon | - |
dc.contributor.author | Kim, Woo Chul | - |
dc.contributor.author | Moon, Sung Ho | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Cho, Jaeho | - |
dc.contributor.author | Park, Hae Jin | - |
dc.contributor.author | Lee, Heui Kwan | - |
dc.contributor.author | Kim, Byoung Hyuck | - |
dc.contributor.author | Kim, Hak Jae | - |
dc.date.accessioned | 2023-05-03T09:42:38Z | - |
dc.date.available | 2023-05-03T09:42:38Z | - |
dc.date.created | 2023-04-06 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/184874 | - |
dc.description.abstract | Purpose: To present the multi-institutional data on patterns of recurrence, treatment approaches, and clinical outcomes for regional lymph node (LN) recurrence after stereotactic body radiation therapy (SBRT) for primary lung cancer. Materials and Methods: The medical records of 114 patients who experienced regional LN recurrence as the first recurrence after lung SBRT were retrospectively reviewed. Patterns of recurrence were classified as local recurrence, regional recurrence, and distant metastasis. Clinical outcomes including progression-free survival (PFS) and overall survival (OS) were analyzed. Results: Half of the patients had regional LN recurrence only. The most common simultaneous recurrence was distant metastasis (38.6 %). Common sites of regional recurrence were ipsilateral hilar (47.2 %), ipsilateral upper mediastinal (40.6 %), and subcarinal (42.5 %) LN stations. 24 (21.1 %) patients underwent salvage radiation therapy (RT), and 44 (38.6 %) patients underwent palliative treatment. Better OS was observed in the salvage RT group (p = 0.025). The 1-year PFS and OS rates were 27.7 % and 55.2 %, respectively, with salvage RT, 14.0 % and 39.9 %, respectively, with palliative treatment, and 22.8 % and 26.8 %, respectively, with no additional treatment. Multivariate analysis showed that salvage RT (PFS, HR 0.463, p = 0.050; OS, HR 0.312, p = 0.002), palliative treatment (PFS, HR 0.436, p = 0.013; OS, HR 0.553, p = 0.050), and simultaneous distant metastasis (PFS, HR 2.335, p = 0.005; OS, HR 1.726, p = 0.054) affected clinical outcomes. Conclusion: Many cases of regional LN recurrence are confined to the locoregional area of patients, and appropriate treatment can improve the prognosis of these patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Ireland Ltd | - |
dc.title | Regional lymph node recurrence after stereotactic body radiation therapy for lung cancer: Patterns of recurrence, treatment approaches, and clinical outcomes (KROG 21-09) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hae Jin | - |
dc.identifier.doi | 10.1016/j.radonc.2023.109572 | - |
dc.identifier.scopusid | 2-s2.0-85149241463 | - |
dc.identifier.wosid | 000954862800001 | - |
dc.identifier.bibliographicCitation | Radiotherapy and Oncology, v.183, pp.1 - 7 | - |
dc.relation.isPartOf | Radiotherapy and Oncology | - |
dc.citation.title | Radiotherapy and Oncology | - |
dc.citation.volume | 183 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | OncologyRadiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | OncologyRadiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | ABLATIVE RADIOTHERAPYPROSPECTIVE TRIALDRAINAGE | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | Lymphatic metastasis | - |
dc.subject.keywordAuthor | Salvage therapy | - |
dc.subject.keywordAuthor | Stereotactic body radiotherapy | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S016781402300110X?via%3Dihub | - |
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