Regional lymph node recurrence after stereotactic body radiation therapy for lung cancer: Patterns of recurrence, treatment approaches, and clinical outcomes (KROG 21-09)
- Authors
- Lee, Tae Hoon; Shin, Hyunju; Ahn, Yong Chan; Kang, Min Kyu; Song, Changhoon; Kim, Woo Chul; Moon, Sung Ho; Kim, Jin Hee; Cho, Jaeho; Park, Hae Jin; Lee, Heui Kwan; Kim, Byoung Hyuck; Kim, Hak Jae
- Issue Date
- Jun-2023
- Publisher
- Elsevier Ireland Ltd
- Keywords
- Lung cancer; Lymphatic metastasis; Salvage therapy; Stereotactic body radiotherapy
- Citation
- Radiotherapy and Oncology, v.183, pp.1 - 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- Radiotherapy and Oncology
- Volume
- 183
- Start Page
- 1
- End Page
- 7
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/184874
- DOI
- 10.1016/j.radonc.2023.109572
- ISSN
- 0167-8140
- Abstract
- Purpose: To present the multi-institutional data on patterns of recurrence, treatment approaches, and clinical outcomes for regional lymph node (LN) recurrence after stereotactic body radiation therapy (SBRT) for primary lung cancer. Materials and Methods: The medical records of 114 patients who experienced regional LN recurrence as the first recurrence after lung SBRT were retrospectively reviewed. Patterns of recurrence were classified as local recurrence, regional recurrence, and distant metastasis. Clinical outcomes including progression-free survival (PFS) and overall survival (OS) were analyzed. Results: Half of the patients had regional LN recurrence only. The most common simultaneous recurrence was distant metastasis (38.6 %). Common sites of regional recurrence were ipsilateral hilar (47.2 %), ipsilateral upper mediastinal (40.6 %), and subcarinal (42.5 %) LN stations. 24 (21.1 %) patients underwent salvage radiation therapy (RT), and 44 (38.6 %) patients underwent palliative treatment. Better OS was observed in the salvage RT group (p = 0.025). The 1-year PFS and OS rates were 27.7 % and 55.2 %, respectively, with salvage RT, 14.0 % and 39.9 %, respectively, with palliative treatment, and 22.8 % and 26.8 %, respectively, with no additional treatment. Multivariate analysis showed that salvage RT (PFS, HR 0.463, p = 0.050; OS, HR 0.312, p = 0.002), palliative treatment (PFS, HR 0.436, p = 0.013; OS, HR 0.553, p = 0.050), and simultaneous distant metastasis (PFS, HR 2.335, p = 0.005; OS, HR 1.726, p = 0.054) affected clinical outcomes. Conclusion: Many cases of regional LN recurrence are confined to the locoregional area of patients, and appropriate treatment can improve the prognosis of these patients.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 방사선종양학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/184874)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.