Low expression of DUSP4 expression predicts unfavorable prognosis in gallbladder adenocarcinoma
- Authors
- Jee, Seungyun; Sim, Jongmin; Bang, Seongsik; Park, Hosub; Myung, Jaekyung; Paik, Seung Sam; Choi, Dongho; Kim, Yeseul; Kim, Hyunsung
- Issue Date
- Oct-2022
- Publisher
- Wolters Kluwer Medknow Publications
- Keywords
- Dual-specificity phosphatase 4; gallbladder adenocarcinoma; immunohistochemistry; prognosis
- Citation
- Indian Journal of Pathology and Microbiology, v.65, no.4, pp.809 - 813
- Indexed
- SCIE
SCOPUS
- Journal Title
- Indian Journal of Pathology and Microbiology
- Volume
- 65
- Number
- 4
- Start Page
- 809
- End Page
- 813
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185205
- DOI
- 10.4103/ijpm.ijpm_352_21
- ISSN
- 0377-4929
- Abstract
- Background: Dual specificity phosphatase 4 (DUSP4), which regulates the mitogen activated protein kinases, has emerged as a tumor suppressor gene in several human malignancies.
Aims and objectives: In this study, we investigated the clinicopathologic significance and the prognostic role of DUSP4 in gallbladder adenocarcinoma. Materials and methods: DUSP4 expression was evaluated immunohistochemically in tissue microarray from 110 gallbladder adenocarcinoma samples and scored by H score system. The cut off (H score <170) was determined by ROC curve analysis. Results: Low expression of DUSP4 expression was observed in 57 (51.8%) out of 110 gallbladder adenocarcinoma samples. Low expression of DUSP4 expression was significantly associated with high histologic grade (P = 0.017), high pT stage (P = 0.002) and high AJCC stage (P = 0.007). Kaplan Meier survival curves revealed that patients with low expression of DUSP4 expression had significantly worse cancer specific survival (P = 0.024, log rank test). However, there was no significant association between DUSP4 expression and recurrence free survival.
Conclusions: In conclusion, gallbladder adenocarcinoma with low expression of DUSP4 expression was associated with adverse clinicopathologic characteristics and poor patient outcome.patient outcome.
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