Nanoscale local hydrogen-bonding sensing using single-molecule spectroscopic imaging
- Authors
- Park, Hyunbum; Kim, Doory
- Issue Date
- Dec-2022
- Publisher
- Elsevier B.V.
- Keywords
- Hydrogen-bonding; Chemical sensing; Super-resolution microscopy; Single-molecule spectroscopy
- Citation
- Sensors and Actuators B: Chemical, v.372, pp.1 - 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- Sensors and Actuators B: Chemical
- Volume
- 372
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185375
- DOI
- 10.1016/j.snb.2022.132593
- ISSN
- 0925-4005
- Abstract
- Hydrogen bonds play significant roles in many chemical and biological processes. However, it remains challenging to probe the local hydrogen-bonding characters at the nanoscale. Herein, we developed a new single-molecule sensing approach to examine the nature of the local hydrogen bonding characters with surrounding molecules at the single-molecule level by employing a single-molecule spectroscopic imaging technique and a Nile blue (NB) dye as a single-molecule sensor. This method is based on the recent developments in single-molecule spectroscopic imaging that enabled local chemical property sensing at the single-molecule level, which is generally masked in the ensemble averages of bulk measurements. By observing the single-molecule fluorescence spectrum of hydrogen-bonding sensor, NB dye, under different chemical conditions, we could differentiate their hydrogen-bonding characteristics at the single-molecule level, even in the solvent mixtures. We believe that the results will be effective in probing different chemical properties of unknown solvent molecules at the single-molecule level, which could not be achieved using any previously reported method.
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