Is Telomere Length Shortening a Risk Factor for Neurodegenerative Disorders?open access
- Authors
- Yu, Hyun-Jung; Koh, Seong-Ho
- Issue Date
- Jul-2022
- Publisher
- 대한치매학회
- Keywords
- Telomere; Neurodegenerative Disorders; Shortening; Alzheimer’s Disease; Parkinson’s Disease; Frontotemporal Dementia
- Citation
- Dementia and Neurocognitive Disorders(대한치매학회지), v.21, no.3, pp.83 - 92
- Indexed
- KCI
- Journal Title
- Dementia and Neurocognitive Disorders(대한치매학회지)
- Volume
- 21
- Number
- 3
- Start Page
- 83
- End Page
- 92
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185511
- DOI
- 10.12779/dnd.2022.21.3.83
- ISSN
- 1738-1495
- Abstract
- Telomeres are located at the end of chromosomes. They are known to protect chromosomes and prevent cellular senescence. Telomere length shortening has been considered an important marker of aging. Many studies have reported this concept in connection with neurodegenerative disorders. Considering the role of telomeres, it seems that longer telomeres are beneficial while shorter telomeres are detrimental in preventing neurodegenerative disorders. However, several studies have shown that people with longer telomeres might also be vulnerable to neurodegenerative disorders. Before these conflicting results can be explained through large-scale longitudinal clinical studies on the role of telomere length in neurodegenerative disorders, it would be beneficial to simultaneously review these opposing results. Understanding these conflicting results might help us plan future studies to reveal the role of telomere length in neurodegenerative disorders. In this review, these contradictory findings are thoroughly discussed, with the aim to better understand the role of telomere length in neurodegenerative disorders.
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