Iontophoretic delivery of dexamethasone-loaded nanoparticles to the anterior segment of the eye
- Authors
- Kim, Se-Na; Min, Chang Hee; Kim, Bo Hee; Lee, Sangjun; Ji, Han Bi; Kim, Cho Rim; Han, Jae Hoon; Im, Chang-Hwan; Yu, Hyeong Gon; Choy, Young Bin
- Issue Date
- Dec-2022
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Anti-inflammation; Dexamethasone; Iontophoresis; Nanoparticles; Ocular drug delivery
- Citation
- Journal of Industrial and Engineering Chemistry, v.116, pp.199 - 206
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Journal of Industrial and Engineering Chemistry
- Volume
- 116
- Start Page
- 199
- End Page
- 206
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185773
- DOI
- 10.1016/j.jiec.2022.09.010
- ISSN
- 1226-086X
- Abstract
- Eye drops are often prescribed for the treatment of inflammatory diseases in the anterior segment of the eye; however, owing to rapid preocular drug clearance, frequent administration is required. In this study, we propose the noninvasive iontophoretic delivery of poly (lactic-co-glycolic acid) nanoparticles loaded with the anti-inflammatory drug dexamethasone (DXT). After topical administration of DXT-loaded nanoparticles (DXT-NP) to the eye, we applied iontophoresis with electrodes attached to the skin of the forehead and eyelid. Iontophoresis increased the amount of DXT-NP permeated into the eye tissues of rabbits by ten folds compared to that without iontophoresis. One-time iontophoretic delivery of DXT-NP released the drug, in a sustained manner, in the aqueous humor of the eye for more than 10 days. In contrast, the drug was cleared rapidly in hours with Maxidex (R), a commercially available eye drop of DXT. Therefore, iontophoretic delivery of DXT-loaded nanoparticles is a promising strategy to enhance drug bioavailability and reduce the frequency of topical drug administration to the eye.
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