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Access toward steroid skeleton and its derivatives via copper-catalyzed intramolecular cyclization: A short synthesis of estradiol and estrone
- Authors
- Liaba, Niaz; Lee, Junseong; Oh, Chang Ho
- Issue Date
- May-2023
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- [4+2] cycloaddition; Cycloisomerization; Cu catalyst; Enyne-carbonyl; estrone; steroids
- Citation
- ASIAN JOURNAL OF ORGANIC CHEMISTRY, v.12, no.5, pp.1 - 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- ASIAN JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 12
- Number
- 5
- Start Page
- 1
- End Page
- 8
- ISSN
- 2193-5807
- Abstract
- A practical and efficient approach leading to [6,6,6,5] tetracyclic fused ring steroid skeletons (8 a–i) has been designed through copper catalyzed intramolecular [4+2] cycloaddition reaction of enyne-carbonyl substrates (7 a–i). The compound 8 a having OMe group at aromatic ring was further utilized to synthesize estradiol and Estrone.
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Related Researcher
- Oh, Chang Ho
- COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF CHEMISTRY)