Roles of Vascular Smooth Muscle Cells in Atherosclerotic Calcificationopen access
- Authors
- Woo, Sang-Ho; Kim, Dae-Yong; Choi, Jae Hoon
- Issue Date
- 1-May-2023
- Publisher
- Korean Society of Lipid and Atherosclerosis
- Keywords
- Atherosclerosis; Calcification; Osteochondrogenic; Vascular smooth muscle cells
- Citation
- Journal of Lipid and Atherosclerosis, v.12, no.2, pp.106 - 118
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of Lipid and Atherosclerosis
- Volume
- 12
- Number
- 2
- Start Page
- 106
- End Page
- 118
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/186348
- DOI
- 10.12997/jla.2023.12.2.106
- ISSN
- 2287-2892
- Abstract
- The accumulation of calcium in atherosclerotic plaques is a prominent feature of advanced atherosclerosis, and it has a strong positive correlation with the total burden of atherosclerosis. Atherosclerotic calcification usually appears first at the necrotic core, indicating that cell death and inflammatory processes are involved in calcification. During atherosclerotic inflammation, various cell types, such as vascular smooth muscle cells, nascent resident pericytes, circulating stem cells, or adventitial cells, have been assumed to differentiate into osteoblastic cells, which lead to vascular calcification. Among these cell types, vascular smooth muscle cells are considered a major contributor to osteochondrogenic cells in the atherosclerotic milieu. In this review, we summarize the molecular mechanisms underlying the osteochondrogenic switch of vascular smooth muscle cells in atherosclerotic plaques.
- Files in This Item
-
- Appears in
Collections - 서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/186348)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.