Apoptosis: a Janus bifrons in T-cell immunotherapy
DC Field | Value | Language |
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dc.contributor.author | Lee, Yong Gu | - |
dc.contributor.author | Yang, Nicholas | - |
dc.contributor.author | Chun, Inkook | - |
dc.contributor.author | Porazzi, Patrizia | - |
dc.contributor.author | Carturan, Alberto | - |
dc.contributor.author | Paruzzo, Luca | - |
dc.contributor.author | Sauter, Christopher Tor | - |
dc.contributor.author | Guruprasad, Puneeth | - |
dc.contributor.author | Pajarillo, Raymone | - |
dc.contributor.author | Ruella, Marco | - |
dc.date.accessioned | 2023-07-27T12:11:29Z | - |
dc.date.available | 2023-07-27T12:11:29Z | - |
dc.date.created | 2023-06-05 | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 2051-1426 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/188334 | - |
dc.description.abstract | Immunotherapy has revolutionized the treatment of cancer. In particular, immune checkpoint blockade, bispecific antibodies, and adoptive T-cell transfer have yielded unprecedented clinical results in hematological malignancies and solid cancers. While T cell-based immunotherapies have multiple mechanisms of action, their ultimate goal is achieving apoptosis of cancer cells. Unsurprisingly, apoptosis evasion is a key feature of cancer biology. Therefore, enhancing cancer cells' sensitivity to apoptosis represents a key strategy to improve clinical outcomes in cancer immunotherapy. Indeed, cancer cells are characterized by several intrinsic mechanisms to resist apoptosis, in addition to features to promote apoptosis in T cells and evade therapy. However, apoptosis is double-faced: when it occurs in T cells, it represents a critical mechanism of failure for immunotherapies. This review will summarize the recent efforts to enhance T cell-based immunotherapies by increasing apoptosis susceptibility in cancer cells and discuss the role of apoptosis in modulating the survival of cytotoxic T lymphocytes in the tumor microenvironment and potential strategies to overcome this issue. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BioMed Central | - |
dc.title | Apoptosis: a Janus bifrons in T-cell immunotherapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Yong Gu | - |
dc.identifier.doi | 10.1136/jitc-2022-005967 | - |
dc.identifier.scopusid | 2-s2.0-85152464607 | - |
dc.identifier.wosid | 000989727900004 | - |
dc.identifier.bibliographicCitation | Journal for ImmunoTherapy of Cancer, v.11, no.4, pp.1 - 13 | - |
dc.relation.isPartOf | Journal for ImmunoTherapy of Cancer | - |
dc.citation.title | Journal for ImmunoTherapy of Cancer | - |
dc.citation.volume | 11 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | TRAIL-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | HUMAN TUMOR-CELLS | - |
dc.subject.keywordPlus | LYMPHOCYTE APOPTOSIS | - |
dc.subject.keywordPlus | INDUCE APOPTOSIS | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | LIGAND TRAIL | - |
dc.subject.keywordPlus | BCL-2 | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | immunotherapy | - |
dc.subject.keywordAuthor | adoptive | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | immunologic | - |
dc.identifier.url | https://www.proquest.com/docview/2800251219?accountid=11283 | - |
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