Apoptosis: a Janus bifrons in T-cell immunotherapyopen access
- Authors
- Lee, Yong Gu; Yang, Nicholas; Chun, Inkook; Porazzi, Patrizia; Carturan, Alberto; Paruzzo, Luca; Sauter, Christopher Tor; Guruprasad, Puneeth; Pajarillo, Raymone; Ruella, Marco
- Issue Date
- Apr-2023
- Publisher
- BioMed Central
- Keywords
- immunotherapy; adoptive; cytotoxicity; immunologic
- Citation
- Journal for ImmunoTherapy of Cancer, v.11, no.4, pp.1 - 13
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal for ImmunoTherapy of Cancer
- Volume
- 11
- Number
- 4
- Start Page
- 1
- End Page
- 13
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/188334
- DOI
- 10.1136/jitc-2022-005967
- ISSN
- 2051-1426
- Abstract
- Immunotherapy has revolutionized the treatment of cancer. In particular, immune checkpoint blockade, bispecific antibodies, and adoptive T-cell transfer have yielded unprecedented clinical results in hematological malignancies and solid cancers. While T cell-based immunotherapies have multiple mechanisms of action, their ultimate goal is achieving apoptosis of cancer cells. Unsurprisingly, apoptosis evasion is a key feature of cancer biology. Therefore, enhancing cancer cells' sensitivity to apoptosis represents a key strategy to improve clinical outcomes in cancer immunotherapy. Indeed, cancer cells are characterized by several intrinsic mechanisms to resist apoptosis, in addition to features to promote apoptosis in T cells and evade therapy. However, apoptosis is double-faced: when it occurs in T cells, it represents a critical mechanism of failure for immunotherapies. This review will summarize the recent efforts to enhance T cell-based immunotherapies by increasing apoptosis susceptibility in cancer cells and discuss the role of apoptosis in modulating the survival of cytotoxic T lymphocytes in the tumor microenvironment and potential strategies to overcome this issue.
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