Rottlerin suppresses lipid accumulation by inhibiting de novo lipogenesis and adipogenesis via LRP6/mTOR/SREBP1C in 3T3-L1 adipocytes
DC Field | Value | Language |
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dc.contributor.author | Kim, Yejin | - |
dc.contributor.author | Kim, Hyun Kyung | - |
dc.contributor.author | Kang, Sumin | - |
dc.contributor.author | Kim, Hayoon | - |
dc.contributor.author | Go, Gwang-woong | - |
dc.date.accessioned | 2023-08-01T06:36:52Z | - |
dc.date.available | 2023-08-01T06:36:52Z | - |
dc.date.created | 2023-07-25 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/188410 | - |
dc.description.abstract | Rottlerin is isolated from Mallotus japonicus, a plant rich in polyphenols. Rottlerin is a selective PKC & delta;-inhibitor and is also known as an uncoupler of oxidative phosphorylation and anti-neoplastic agent. However, its anti-obesity effect is yet to be established. Therefore, this study tested whether rottlerin inhibits adipogenesis and de novo lipogenesis via the LRP6/mTOR/SREBP1C pathway in 3T3-L1 adipocytes. Rottlerin dramatically decreased lipid accumulation assessed by Oil Red O as evidence to support the cellular phenotype (p < 0.001). Pivotal messenger RNA and protein expressions associated with de novo lipogenesis (SREBP1C, ACC1, FAS, and SCD1) and adipogenesis (PPAR & gamma; and C/EBP & alpha;) were subsequentially verified by rottlerin in a dose-dependent manner (p < 0.05). Further investigation revealed that rottlerin reduced the AKT/mTOR pathway via diminished total protein of LRP6 (p < 0.05). Collectively, these findings establish a causal link between rottlerin, LRP6, and the altered nutrient-sensing mTOR pathway, in which rottlerin regulates de novo lipogenesis and adipogenesis in white adipocytes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.title | Rottlerin suppresses lipid accumulation by inhibiting de novo lipogenesis and adipogenesis via LRP6/mTOR/SREBP1C in 3T3-L1 adipocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Go, Gwang-woong | - |
dc.identifier.doi | 10.1007/s10068-023-01339-5 | - |
dc.identifier.scopusid | 2-s2.0-85163788580 | - |
dc.identifier.wosid | 001020141900003 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.32, no.10, pp.1445 - 1452 | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 32 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1445 | - |
dc.citation.endPage | 1452 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002981159 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | FATTY LIVER-DISEASE | - |
dc.subject.keywordPlus | PROTEIN 6 LRP6 | - |
dc.subject.keywordPlus | WNT/BETA-CATENIN | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | HYPERLIPIDEMIA | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordAuthor | Rottlerin | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | De novo lipogenesis | - |
dc.subject.keywordAuthor | The nutrient-sensing mTOR pathway | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10068-023-01339-5 | - |
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