Prevalence, incidence and cause-specific mortality of rheumatoid arthritis-associated interstitial lung disease among older rheumatoid arthritis patientsopen access
- Authors
- Sparks, Jeffrey A; Jin, Yinzhu; Cho, Soo Kyung; Vine, Seanna; Desai, Rishi; Doyle, Tracy J; Kim, Seoyoung C
- Issue Date
- Aug-2021
- Publisher
- OXFORD UNIV PRESS
- Keywords
- rheumatoid arthritis; interstitial lung disease; epidemiology; respiratory; mortality
- Citation
- RHEUMATOLOGY, v.60, no.8, pp.3689 - 3698
- Indexed
- SCIE
SCOPUS
- Journal Title
- RHEUMATOLOGY
- Volume
- 60
- Number
- 8
- Start Page
- 3689
- End Page
- 3698
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189181
- DOI
- 10.1093/rheumatology/keaa836
- ISSN
- 1462-0324
- Abstract
- Objective. We aimed to investigate the prevalence, incidence and cause-specific mortality of RA-associated interstitial lung disease (RA-ILD) among older US patients with RA.
Methods. We performed a nationwide cohort study using Medicare claims data (parts A, B and D for 2008-2017). RA was identified with a validated algorithm using RA diagnosis codes and DMARD prescription. RA-ILD was identified with a validated algorithm using ILD diagnosis codes by a rheumatologist/pulmonologist. RA-ILD was categorized as prevalent or incident relative to the initial RA observation (baseline/index date). We compared the total mortality of RA-ILD to RA without ILD using multivariable Cox regression, adjusting for baseline covariates. For cause-specific mortality, Fine and Gray subdistribution hazard ratios (sdHRs) were estimated to handle competing risks of alternative mortality causes.
Results. Among 509 787 RA patients (mean age 72.6 years, 76.2% female), 10 306 (2.0%) had prevalent RA-ILD at baseline. After baseline, 13 372 (2.6%) developed RA-ILD during 1 873 127 person-years of follow-up (median 3.0 years/person). During follow-up, 38.7% of RA-ILD patients died compared with 20.7% of RA patients without ILD. After multivariable adjustment, RA-ILD had an HR of 1.66 (95% CI 1.60, 1.72) for total mortality. Accounting for competing risk of other causes of death, RA-ILD had an sdHR of 4.39 (95% CI 4.13, 4.67) for respiratory mortality and an sdHR of 1.56 (95% CI 1.43, 1.71) for cancer mortality compared with RA without ILD.
Conclusions. RA-ILD was present or developed in nearly 5% of patients in this nationwide study of older patients with RA. Compared with RA without ILD, RA-ILD was associated with excess total, respiratory and cancer mortality that was not explained by measured factors.
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