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Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Park, Sung-Jin | - |
| dc.contributor.author | Kim, Beomsue | - |
| dc.contributor.author | Choi, Sejong | - |
| dc.contributor.author | Balasubramaniam, Sivaraman | - |
| dc.contributor.author | Lee, Sung-Chan | - |
| dc.contributor.author | Lee, Jung Yeol | - |
| dc.contributor.author | Kim, Heon Seok | - |
| dc.contributor.author | Kim, Jun-Young | - |
| dc.contributor.author | Kim, Jong-Jin | - |
| dc.contributor.author | Lee, Yong-An | - |
| dc.contributor.author | Kang, Nam-Young | - |
| dc.contributor.author | Kim, Jin-Soo | - |
| dc.contributor.author | Chang, Young-Tae | - |
| dc.date.accessioned | 2023-08-22T03:06:06Z | - |
| dc.date.available | 2023-08-22T03:06:06Z | - |
| dc.date.created | 2023-07-21 | - |
| dc.date.issued | 2019-03 | - |
| dc.identifier.issn | 2041-1723 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189461 | - |
| dc.description.abstract | Activated macrophages have the potential to be ideal targets for imaging inflammation. However, probe selectivity over non-activated macrophages and probe delivery to target tissue have been challenging. Here, we report a small molecule probe specific for activated macrophages, called CDg16, and demonstrate its application to visualizing inflammatory atherosclerotic plaques in vivo. Through a systematic transporter screen using a CRISPR activation library, we identify the orphan transporter Slc18b1/SLC18B1 as the gating target of CDg16. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | NATURE PUBLISHING GROUP | - |
| dc.title | Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Kim, Heon Seok | - |
| dc.identifier.doi | 10.1038/s41467-019-08990-9 | - |
| dc.identifier.scopusid | 2-s2.0-85062628220 | - |
| dc.identifier.wosid | 000460510000008 | - |
| dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.10, no.1, pp.1 - 7 | - |
| dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
| dc.citation.title | NATURE COMMUNICATIONS | - |
| dc.citation.volume | 10 | - |
| dc.citation.number | 1 | - |
| dc.citation.startPage | 1 | - |
| dc.citation.endPage | 7 | - |
| dc.type.rims | ART | - |
| dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
| dc.description.journalClass | 1 | - |
| dc.description.isOpenAccess | Y | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
| dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
| dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
| dc.subject.keywordPlus | TRANSPORT | - |
| dc.subject.keywordPlus | DISEASE | - |
| dc.subject.keywordPlus | CELLS | - |
| dc.identifier.url | https://www.nature.com/articles/s41467-019-08990-9 | - |
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Related Researcher
- Kim, Heon Seok
- COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF LIFE SCIENCE)