Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating targetopen access
- Authors
- Park, Sung-Jin; Kim, Beomsue; Choi, Sejong; Balasubramaniam, Sivaraman; Lee, Sung-Chan; Lee, Jung Yeol; Kim, Heon Seok; Kim, Jun-Young; Kim, Jong-Jin; Lee, Yong-An; Kang, Nam-Young; Kim, Jin-Soo; Chang, Young-Tae
- Issue Date
- Mar-2019
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE COMMUNICATIONS, v.10, no.1, pp.1 - 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- NATURE COMMUNICATIONS
- Volume
- 10
- Number
- 1
- Start Page
- 1
- End Page
- 7
- ISSN
- 2041-1723
- Abstract
- Activated macrophages have the potential to be ideal targets for imaging inflammation. However, probe selectivity over non-activated macrophages and probe delivery to target tissue have been challenging. Here, we report a small molecule probe specific for activated macrophages, called CDg16, and demonstrate its application to visualizing inflammatory atherosclerotic plaques in vivo. Through a systematic transporter screen using a CRISPR activation library, we identify the orphan transporter Slc18b1/SLC18B1 as the gating target of CDg16.
- Files in This Item
- Appears in
Collections - 서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Kim, Heon Seok
- COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF LIFE SCIENCE)