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Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population
- Authors
- Kim Jung Oh; Kim Hyun Woo; An Hui Jeong; Kim Ok Joon; Oh Jisu; Chong So Young; Choi, Wonil; Oh Doyeun; Kim Nam Keun
- Issue Date
- Feb-2019
- Publisher
- SPRINGER
- Keywords
- Deep vein thrombosis; MicroRNA; Single nucleotide polymorphism; Pulmonary embolism
- Citation
- JOURNAL OF THROMBOSIS AND THROMBOLYSIS, v.47, no.2, pp.255 - 262
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THROMBOSIS AND THROMBOLYSIS
- Volume
- 47
- Number
- 2
- Start Page
- 255
- End Page
- 262
- ISSN
- 0929-5305
- Abstract
- Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. We observed no statistically significant differences in the genotype frequency of miRNA polymorphisms between 300 control individuals and 203 VTE patients. However, we observed a significant association between three allelic combinations of miRNA polymorphisms and VTE risk. Overall, our findings suggest that specific miRNA polymorphisms are associated with the risk of VTE in a Korean population.
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Related Researcher
- Choi, Wonil
- COLLEGE OF MEDICINE (DEPARTMENT OF MEDICAL COOPERATION)