CD56(+)CD57(+) infiltrates as the most predominant subset of intragraft natural killer cells in renal transplant biopsies with antibody- mediated rejectionopen access
- Authors
- Jung, Hey Rim; Kim, Mi Joung; Wee, Yu-Mee; Kim, Jee Yeon; Choi, Monica Young; Choi, Ji Yoon; Kwon, Hyunwook; Jung, Joo Hee; Cho, Yong Mee; Go, Heounjeong; Kim, Sang-Yeob; Ryu, Yeon-Mi; Kim, Yun Jae; Kim, Young Hoon; Han, Duck Jong; Shin, Sung
- Issue Date
- Nov-2019
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.9, no.1, pp.1 - 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 9
- Number
- 1
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189479
- DOI
- 10.1038/s41598-019-52864-5
- ISSN
- 2045-2322
- Abstract
- Little is known about the characteristics and clinical implications of specific subsets of intragraft natural killer (NK) cells in kidney transplant recipients. We analyzed 39 for-cause renal transplant biopsies performed at our center from May 2015 to July 2017. According to histopathologic reports, 8 patients (20.5%) had no rejection (NR), 11 (28.2%) had T cell-mediated rejections (TCMR) only, and 20 (51.3%) had antibody-mediated rejection (ABMR). NK cells were defined as CD3 CD56(+) lymphocytes that are positive for CD57, CD49b, NKG2A, or KIR. The density of NK cells was significantly higher in the ABMR group (2.57 +/- 2.58/mm(2)) than in the NR (0.12 +/- 0.22/mm(2)) or the TCMR (0.25 +/- 0.34/mm(2)) group (P= 0.002). Notably, CD56(+)CD57(+) infiltrates (2.16 +/- 1.89) were the most frequently observed compared with CD56(+)CD49b(+) (0.05 +/- 0.13), CD56(+)NKG2A(+) (0.21 +/- 0.69), and CD56(+)KIR(+) (0.15 +/- 0.42) cells in the ABMR group (P < 0.001). Death-censored graft failure was significantly higher in patients with NK cell infiltration than those without (Log-rank test, P= 0.025). In conclusion, CD56(+)CD57(+) infiltrates are a major subset of NK cells in kidney transplant recipients with ABMR and NK cell infiltration is significantly associated with graft failure post-transplant.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 외과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189479)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.