A secure system for genomics clinical decision support
- Authors
- Kim, Miran; Karimi Seemeen; Jiang Xiaoqian; Dolin Robert H.; Boxwala Aziz
- Issue Date
- Dec-2020
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Genome archiving and communications system; Genomic computation; Homomorphic encryption; Secure clinical decision support; Secure outsourcing
- Citation
- JOURNAL OF BIOMEDICAL INFORMATICS, v.112, pp.1 - 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF BIOMEDICAL INFORMATICS
- Volume
- 112
- Start Page
- 1
- End Page
- 8
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189494
- DOI
- 10.1016/j.jbi.2020.103602
- ISSN
- 1532-0464
- Abstract
- We developed a prototype genomic archiving and communications system to securely store genome data and provide clinical decision support (CDS). This system operates on a client-server model. The client encrypts the data, and the server stores data and performs the computations necessary for CDS. Computations are directly performed on encrypted data, and the client decrypts results. The server cannot decrypt inputs or outputs, which provides strong guarantees of security. We have validated our system with three genomics-based CDS applications. The results demonstrate that it is possible to resolve a long-standing dilemma in genomic data privacy and accessibility, by using a principled cryptographical framework and a mathematical representation of genome data and CDS questions.
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