Galectin-4 increases the ability of M2 macrophages to enhance antiviral CD4(+) T-cell responses
DC Field | Value | Language |
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dc.contributor.author | Lee, In-Gu | - |
dc.contributor.author | Joo, Yong-Hyun | - |
dc.contributor.author | Jeon Hoyeon | - |
dc.contributor.author | Jeong, Raehyuk | - |
dc.contributor.author | Kim, Eui Ho | - |
dc.contributor.author | Chung, Hyunwoo | - |
dc.contributor.author | Eyun, Seong-il | - |
dc.contributor.author | Kim, Jeongkyu | - |
dc.contributor.author | Seo, Young-Jin | - |
dc.contributor.author | Hong, So-Hee | - |
dc.date.accessioned | 2023-09-04T07:49:11Z | - |
dc.date.available | 2023-09-04T07:49:11Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.issn | 1938-3673 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189941 | - |
dc.description.abstract | Gal-4 enhances the immunostimulatory activity of M2 macrophages upon viral infection, leading to the reinforced antiviral functionality of CD4(+) T cells.,Galectin-4 (Gal-4) is a beta-galactoside-binding protein belonging to the galectin family. Although Gal-4 is known to be involved in several physiologic processes of the gastrointestinal tract, its immunomodulatory roles remain unclear. In this study, we investigated whether Gal-4 influences the function of M1 and M2 macrophages. Gal-4 treatment drove more robust changes in the gene expression of M2 macrophages compared to M1 macrophages. Antiviral immune response-related genes were significantly upregulated in Gal-4-treated M2 macrophages. Gal-4 significantly enhanced the immunostimulatory activity of M2 macrophages upon Toll-like receptor 7 stimulation or infection with lymphocytic choriomeningitis virus (LCMV). Moreover, the antibody production against LCMV infection and the antiviral CD4(+) T-cell responses, but not the antiviral CD8(+) T-cell responses, were greatly increased by Gal-4-treated M2 macrophages in vivo. The present results indicate that Gal-4 enhances the ability of M2 macrophages to promote antiviral CD4(+) T-cell responses. Thus, Gal-4 could be used to boost antiviral immune responses. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Galectin-4 increases the ability of M2 macrophages to enhance antiviral CD4(+) T-cell responses | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1093/jleuko/qiac008 | - |
dc.identifier.scopusid | 2-s2.0-85148682575 | - |
dc.identifier.wosid | 000911647700007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.113, no.1, pp 71 - 83 | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 113 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 71 | - |
dc.citation.endPage | 83 | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DOMAINS | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | LECTIN | - |
dc.subject.keywordAuthor | galectin-4 | - |
dc.subject.keywordAuthor | M1 macrophage | - |
dc.subject.keywordAuthor | M2 macrophage | - |
dc.subject.keywordAuthor | CD4(+) T cell | - |
dc.subject.keywordAuthor | lymphocytic choriomeningitis virus | - |
dc.identifier.url | https://academic.oup.com/jleukbio/article/113/1/71/6979761 | - |
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