Galectin-4 increases the ability of M2 macrophages to enhance antiviral CD4(+) T-cell responses
- Authors
- Lee, In-Gu; Joo, Yong-Hyun; Jeon Hoyeon; Jeong, Raehyuk; Kim, Eui Ho; Chung, Hyunwoo; Eyun, Seong-il; Kim, Jeongkyu; Seo, Young-Jin; Hong, So-Hee
- Issue Date
- Jan-2023
- Publisher
- OXFORD UNIV PRESS
- Keywords
- galectin-4; M1 macrophage; M2 macrophage; CD4(+) T cell; lymphocytic choriomeningitis virus
- Citation
- JOURNAL OF LEUKOCYTE BIOLOGY, v.113, no.1, pp 71 - 83
- Pages
- 13
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF LEUKOCYTE BIOLOGY
- Volume
- 113
- Number
- 1
- Start Page
- 71
- End Page
- 83
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189941
- DOI
- 10.1093/jleuko/qiac008
- ISSN
- 0741-5400
1938-3673
- Abstract
- Gal-4 enhances the immunostimulatory activity of M2 macrophages upon viral infection, leading to the reinforced antiviral functionality of CD4(+) T cells.,Galectin-4 (Gal-4) is a beta-galactoside-binding protein belonging to the galectin family. Although Gal-4 is known to be involved in several physiologic processes of the gastrointestinal tract, its immunomodulatory roles remain unclear. In this study, we investigated whether Gal-4 influences the function of M1 and M2 macrophages. Gal-4 treatment drove more robust changes in the gene expression of M2 macrophages compared to M1 macrophages. Antiviral immune response-related genes were significantly upregulated in Gal-4-treated M2 macrophages. Gal-4 significantly enhanced the immunostimulatory activity of M2 macrophages upon Toll-like receptor 7 stimulation or infection with lymphocytic choriomeningitis virus (LCMV). Moreover, the antibody production against LCMV infection and the antiviral CD4(+) T-cell responses, but not the antiviral CD8(+) T-cell responses, were greatly increased by Gal-4-treated M2 macrophages in vivo. The present results indicate that Gal-4 enhances the ability of M2 macrophages to promote antiviral CD4(+) T-cell responses. Thus, Gal-4 could be used to boost antiviral immune responses.
- Files in This Item
-
Go to Link
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189941)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.