Simple Tandem Olefin Isomerization/Intramolecular Hydroamination of Alkenyl Amines with Various Allylic Tethers
- Authors
- Kim, Young Ho; Bin Kim, Dong; Youn, So Won
- Issue Date
- Sep-2022
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF ORGANIC CHEMISTRY, v.87, no.17, pp.11919 - 11924
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 87
- Number
- 17
- Start Page
- 11919
- End Page
- 11924
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/190090
- DOI
- 10.1021/acs.joc.2c01640
- ISSN
- 0022-3263
- Abstract
- A simple and efficient AgOTf-promoted tandem olefin isomerization/intramolecular hydroamination of 1,1-disub-stituted alkenyl amines has been developed. This one-pot process represents a facile and attractive route for the synthesis of diverse 2-alkyl-substituted 1,3-X,N-heterocycles through chemo-and regiose-lective C(sp3)-N bond formation with atom economy. Advantages such as the operationally simple and practical procedure that uses a readily available catalyst under aerobic conditions, good to excellent chemical yields, the high functional group tolerance, the broad substrate scope, and high efficiency and selectivity are noteworthy.
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