The change in prevalence of suspected non-alcoholic fatty liver disease in Korean adolescents from 2001 to 2017
- Authors
- Oh, Eun Hye; Park, Seung Ha; Park, Yong Eun; Lee, Jin; Choi, Joon Hyuk; Heo, Nae Yun; Park, Jongha; Kim, Tae Oh; Hwang, Jun Seong; Kim, Eunju; Jang, Hang Jea; Park, Ha Young; Kim, Hyun Kuk
- Issue Date
- Jul-2020
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Adolescent; non-alcoholic fatty liver disease; obesity; prevalence
- Citation
- PAEDIATRICS AND INTERNATIONAL CHILD HEALTH, v.40, no.3, pp.166 - 170
- Indexed
- SCIE
SCOPUS
- Journal Title
- PAEDIATRICS AND INTERNATIONAL CHILD HEALTH
- Volume
- 40
- Number
- 3
- Start Page
- 166
- End Page
- 170
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/190148
- DOI
- 10.1080/20469047.2020.1747002.
- ISSN
- 2046-9047
- Abstract
- Aim: Data on trends in the prevalence of suspected non-alcoholic fatty liver disease (NAFLD) in adolescents are scarce, especially in the Asia-Pacific region. The purpose of this study was to determine whether the prevalence of suspected NAFLD changed between 2001-2005 and 2015-2017. Methods: Data were extracted from the Korea National Health and Nutrition Examination Survey (2001-2005 to 2015-2017, n = 4448). Suspected NAFLD was defined by an elevated alanine aminotransferase (ALT) level of >26 IU/L in boys and >22 IU/L in girls. In addition, the analysis was repeated using the Korean cut-off levels for ALT of 33 IU/L for boys and 25 IU/L for girls. Results: The prevalence of suspected NAFLD increased, with a relative increase of 44% from 7.8% (95% CI 6.6-9.2%) in 2001-2005 to 11.2% (95% CI 9.7-12.9%) in 2015-2017 (p = 0.001). This increase was evident in both boys (10.6 vs 14.7%, p = 0.01) and girls (4.6 vs 7.4%, p = 0.02). Increases were also observed in obesity (7.3 vs 10.6%), central obesity (10.0 vs 12.8%) and ALT level (14.9 vs 16.7 IU/L). The prevalence of suspected NAFLD was approximately 40-45% in obese/central obese adolescents in 2015-2017. Using the Korean cut-off levels, the prevalence of suspected NAFLD has increased, with a relative increase of 55%, from 4.6% (95% CI 3.7-5.7%) in 2001-2005 to 7.2% (95% CI 6.1-8.5%) in 2015-2017 (p = 0.01). Conclusions: The prevalence of suspected NAFLD continues to increase in Korean adolescents.
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