Comparing effectiveness of polydeoxyribonucleotide injection and corticosteroid injection in plantar fasciitis treatment: A prospective randomized clinical study
- Authors
- Lee, Dong-Oh; Yoo, Jeong-Hyun; Cho, Hyung-In; Cho, Soonghwan; Cho, Hyung Rae
- Issue Date
- Aug-2020
- Publisher
- ELSEVIER
- Keywords
- Plantar fasciitis; Conservative treatment; Injection; Polydeoxyribonucleotide (PDRN); Corticosteroid
- Citation
- FOOT AND ANKLE SURGERY, v.26, no.6, pp.657 - 661
- Indexed
- SCIE
SCOPUS
- Journal Title
- FOOT AND ANKLE SURGERY
- Volume
- 26
- Number
- 6
- Start Page
- 657
- End Page
- 661
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/190732
- DOI
- 10.1016/j.fas.2019.08.005
- ISSN
- 1268-7731
- Abstract
- Background: This study aimed to compare the efficacy and safety of polydeoxyribonucleotide (PDRN) injection and corticosteroid injection for plantar fasciitis. Methods: This study included 44 patients with plantar fasciitis, randomly allocated to the PDRN and corticosteroid groups. Evaluation using the visual analogue scale (VAS) pain score and Manchester-Oxford foot questionnaire (MOXFQ) was conducted at baseline, 1, 2, 6 weeks and 6 months. The thickness and echogenicity of the plantar fascia in ultrasonography and complications were recorded. Results: Corticosteroid injection elicited more pain relief than did PDRN injection at 2 (p =0.010) and 6 weeks (p= 0.016); however, it showed no superiority at 6 months (p =0.523). MOXFQ showed similar outcomes. The thickness and echogenicity did not differ between groups and no complications were reported in either group. Conclusions: We demonstrated that PDRN injection could be an effective and safe option for plantar fasciitis and was comparable to corticosteroid injection after 6 months follow up. (C) 2019 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
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