Synergistic antidepressant-like effect of n-3 polyunsaturated fatty acids and probiotics through the brain-gut axis in rats exposed to chronic mild stress
DC Field | Value | Language |
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dc.contributor.author | Cho, Hyunji | - |
dc.contributor.author | Jo, Miyea | - |
dc.contributor.author | Oh, Haemin | - |
dc.contributor.author | Lee, Yunjung | - |
dc.contributor.author | Park, Yongsoon | - |
dc.date.accessioned | 2023-10-04T06:30:27Z | - |
dc.date.available | 2023-10-04T06:30:27Z | - |
dc.date.created | 2023-05-03 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/191579 | - |
dc.description.abstract | N-3 polyunsaturated fatty acids (PUFA) and probiotics have antidepressant-like effects, but the underlying mechanisms are unclear. We hypothesized that n-3 PUFA combined with live and dead probiotics synergistically improves depression by modulating the hypothalamic-pituitary-adrenal (HPA) axis and serotonergic pathways through the brain-gut axis. Rats were randomly divided into seven groups (n = 8/group): nonchronic mild stress (CMS) with n-6 PUFA, CMS with n-3 PUFA, n-6 PUFA, live probiotics, dead probiotics, n-3 PUFA, and live probiotics, and n-3 PUFA and dead probiotics. Diets of n-6 and n-3 PUFA and oral supplementation of live and dead probiotics were provided for 12 weeks, and CMS was performed for the last 5 weeks. N-3 PUFA and probiotics improved depressive behaviors and modulated the brain and gut HPA axis by synergistically increasing glucocorticoid receptor expression and decreasing corticotropin-releasing factor expression and blood levels of adrenocorticotropic hormone and corticosterone. N-3 PUFA and probiotics upregulated the brain serotonergic pathway through serotonin levels and expression of brain-derived neurotrophic factor, phosphorylated cAMP response binding protein, and 5-hydroxytryptamine 1A receptor while downregulating the gut serotonergic pathway. Furthermore, n-3 PUFA and probiotics increased the abundance of Ruminococcaceae, brain and gut short chain fatty acid levels, and occludin expression while decreasing the expression of tumor necrosis factor-α, interleukin-1β, and prostaglandin E2 and blood lipopolysaccharides levels. There was no significant difference between the live and dead probiotics. In conclusion, n-3 PUFA and probiotics had synergistic antidepressant-like effects on the HPA axis and serotonergic pathways of the brain and gut through the brain-gut axis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Synergistic antidepressant-like effect of n-3 polyunsaturated fatty acids and probiotics through the brain-gut axis in rats exposed to chronic mild stress | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.identifier.doi | 10.1016/j.jnutbio.2023.109326 | - |
dc.identifier.scopusid | 2-s2.0-85151622232 | - |
dc.identifier.wosid | 000981075500001 | - |
dc.identifier.bibliographicCitation | Journal of Nutritional Biochemistry, v.116, pp.1 - 12 | - |
dc.relation.isPartOf | Journal of Nutritional Biochemistry | - |
dc.citation.title | Journal of Nutritional Biochemistry | - |
dc.citation.volume | 116 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | 5-HT1A RECEPTORS | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | BDNF | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Brain-gut axis | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | HPA axis | - |
dc.subject.keywordAuthor | N-3 PUFA | - |
dc.subject.keywordAuthor | Probiotics | - |
dc.subject.keywordAuthor | Serotonergic pathway | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0955286323000591?via%3Dihub | - |
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