A comprehensive and systemic review of ginseng-based nanomaterials: Synthesis, targeted delivery, and biomedical applicationsopen access
- Authors
- Balusamy, Sri Renukadevi; Perumalsamy, Haribalan; Huq, Md. Amdadul; Yoon, Tae Hyun; Mijakovic, Ivan; Thangavelu, Lakshmi; Yang, Deok Chun; Rahimi, Shadi
- Issue Date
- Sep-2023
- Publisher
- WILEY
- Keywords
- biomedical applications; ginseng nanoparticle synthesis; ginsenoside based nanoparticles; green synthesis; microbial synthesis; Panax species; polymer-based ginsenoside nanocarrier; targeted delivery
- Citation
- MEDICINAL RESEARCH REVIEWS, v.43, no.5, pp.1374 - 1410
- Indexed
- SCIE
SCOPUS
- Journal Title
- MEDICINAL RESEARCH REVIEWS
- Volume
- 43
- Number
- 5
- Start Page
- 1374
- End Page
- 1410
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/191599
- DOI
- 10.1002/med.21953
- ISSN
- 0198-6325
- Abstract
- Among 17 Panax species identified across the world, Panax ginseng (Korean ginseng), Panax quinquefolius (American ginseng), and Panax notoginseng (Chinese ginseng) are highly recognized for the presence of bioactive compound, ginsenosides and their pharmacological effects. P. ginseng is widely used for synthesis of different types of nanoparticles compared to P. quinquefolius and P. notoginseng. The use of nano-ginseng could increase the oral bioavailability, membrane permeability, and thus provide effective delivery of ginsenosides to the target sites through transport system. In this review, we explore the synthesis of ginseng nanoparticles using plant extracts from various organs, microbes, and polymers, as well as their biomedical applications. Furthermore, we highlight transporters involved in transport of ginsenoside nanoparticles to the target sites. Size, zeta potential, temperature, and pH are also discussed as the critical parameters affecting the quality of ginseng nanoparticles synthesis.
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